PROMOTER FROM ASHBYA GOSSYPII

Enzymes involved in purine biosynthesis in Ashbya gossypii are new. hosphoribosylpyrophosphate synthetases (KPR1 and 2) comprising 318 or 320 amino acid residues, glutamine-phosphororibosylpyrophosphate amidotransferase (ADE4) comprising 510 amino acid residues, IMP-dehydrogenase (GUA1) comprising 1...

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Bibliographic Details
Main Authors SANTOS GARCIA, MARIA ANGELES, SEULBERGER, HARALD, REVUELTA DOVAL, JOSE LUIS, POMPEJUS, MARKUS
Format Patent
LanguageEnglish
French
German
Published 17.11.2004
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Enzymes involved in purine biosynthesis in Ashbya gossypii are new. hosphoribosylpyrophosphate synthetases (KPR1 and 2) comprising 318 or 320 amino acid residues, glutamine-phosphororibosylpyrophosphate amidotransferase (ADE4) comprising 510 amino acid residues, IMP-dehydrogenase (GUA1) comprising 151 or 371 amino acid residues, and a GMP-synthetase (GUA2) comprising 525 amino acid residues or polypeptides with substitution, insertion or deletion of 10-20 % of the amino acid sequence, and the activity of the relative enzyme are new (all sequences fully defined in the specification). Independent claims are also included for: (1) nucleic acid sequences encoding the above enzymes; and (2) the production riboflavin comprising cultivation of a microorganism genetically modified with at least one gene for purine biosynthesis.
Bibliography:Application Number: EP19980966671