OSTEOBLAST-SPECIFIC MITOGENS AND DRUGS CONTAINING SUCH COMPOUNDS

New and known lysophosphatidyl acids (I) are useful for treating bone metabolism disorders such as osteoporosis, and for healing bones and wounds. The use of lysophosphatidyl acids of formula (I) and their salts, esters, derivatives and enantiomers/racemates is claimed for treating bone metabolism d...

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Bibliographic Details
Main Authors ESSWEIN, ANGELIKA, KLING, LOTHAR
Format Patent
LanguageEnglish
French
German
Published 05.02.2003
Edition7
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New and known lysophosphatidyl acids (I) are useful for treating bone metabolism disorders such as osteoporosis, and for healing bones and wounds. The use of lysophosphatidyl acids of formula (I) and their salts, esters, derivatives and enantiomers/racemates is claimed for treating bone metabolism disorders. R1 = 6-24C alkyl, alkenyl or alkynyl; n = 0-12; X = O or NH. (I) are new, provided that when X = O, then n is not 7, 9, 11, 13 or 15. The following compounds are also excepted: (all-cis-5,8,11,14)-eicosatetraenoic acid-2-hydroxy-3-phosphonooxypropyl ester, cis-9,cis-12-octadecadienoic acid-2-hydroxy-3-phosphonooxypropyl ester, (all-cis-9,12,15)-octadecatrienoic acid-2-hydroxy-3-phosphonooxypropyl ester or cis-9-octadecenoic acid-2-hydroxy-3-phosphonooxypropyl ester.
Bibliography:Application Number: EP19980954302