CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF
A method of inhibiting topoisomerase I mediated DNA cleavage including administering a pharmaceutically effective amount of a compound having the following formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are independently the same or different and are hydrogen, an alkyl grou...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
24.12.2008
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Subjects | |
Online Access | Get full text |
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Summary: | A method of inhibiting topoisomerase I mediated DNA cleavage including administering a pharmaceutically effective amount of a compound having the following formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are independently the same or different and are hydrogen, an alkyl group, an aminoalkyl group, an alkylaminoalkyl group, a haloalkyl group, a hydroxyalkyl group, an alkenyl group, an alkynyl group, an alkoxyl group, an aryloxy group, a carbamoyloxy group, a halogen, a hydroxyl group, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, -C(O)Rf, an amino group, an alkylamino group, a dialkylamino group, -SRc, wherein Rc is hydrogen, -OC(O)Rd or -OC(O)ORd, wherein Rd is an alkyl group; or R1 and R2 together form a group of the formula -O(CH2)nO- wherein n represents the integer 1 or 2; R3 is H, F, a halogen atom, a nitro group, an amino group, a hydroxyl group, or a cyano group; or R2 and R3 together form -O(CH2)nO- (n=1 or 2); R4 is H, F, a C1-3 alkyl group, a C2-3 alkenyl group, a C2-3 alkynyl group, or a C1-3 alkoxyl group; R5 is a C1-10 alkyl group, or a propargyl group. |
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Bibliography: | Application Number: EP19980944535 |