COMPOSITIONS FOR ENHANCING IMMUNOSUPPRESSANTS' PHARMACOLOGICAL ACTIVITIES

The present invention provides the compositions for efficient amplification of immunosuppressive activity of cyclosporins, FK506 or rapamycin to decrease therapeutical dose of immunosuppressants, and as the consequence to avoid their undesirable side effects during organ and tissue transplantation,...

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Main Authors KORPELA, TIMO KALEVI, ZAVIALOV, VLADIMIR PETROVICH, DOLGIKH, DMITRY ALEKSANDROVICH, KIRPICHNIKOV, MIKHAIL PETROVICH, VASILENKO, RAISA NIKOLAEVNA, NAVOLOTSKAYA, ELENA VITALIEVNA
Format Patent
LanguageEnglish
French
German
Published 19.03.2003
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides the compositions for efficient amplification of immunosuppressive activity of cyclosporins, FK506 or rapamycin to decrease therapeutical dose of immunosuppressants, and as the consequence to avoid their undesirable side effects during organ and tissue transplantation, and treatment of different diseases. These compositions include cyclosporins, FK506 or rapamycin and biologically active peptides corresponding to the high-affinity binding/anti-lymphoproliferative site of IFNs-a,b,w,t, or recombinant proteins having the amino acid sequences corresponding to the said site.
Bibliography:Application Number: EP19980921528