Preparation of 2-substituted pyridines
This invention relates to a process for preparing 2-substituted pyridines via metal halogen exchange with sec-butyllithium on optionally substituted 2-bromo or 2-iodopyridines. The resulting lithopyridine intermediate is reacted with an electrophile to provide the desired 2-substituted pyridine. The...
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Main Authors | , |
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Format | Patent |
Language | English French German |
Published |
10.11.1999
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | This invention relates to a process for preparing 2-substituted pyridines via metal halogen exchange with sec-butyllithium on optionally substituted 2-bromo or 2-iodopyridines. The resulting lithopyridine intermediate is reacted with an electrophile to provide the desired 2-substituted pyridine. The substitution of sec-butyllithium for n-butyllithium in such a process results in an enhanced yield and purity of the desired 2-substituted pyridine. |
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Bibliography: | Application Number: EP19990303341 |