PROCESS FOR PREPARING A NAPHTALENAMINE DERIVATIVE

PCT No. PCT/HU97/00083 Sec. 371 Date Jul. 27, 1999 Sec. 102(e) Date Jul. 27, 1999 PCT Filed Dec. 15, 1997 PCT Pub. No. WO98/27050 PCT Pub. Date Jun. 25, 1998The present invention relates to a proccss for preparing cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphtalenamine and its a...

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Main Authors FODOR, TAMAS, VUKICS, KRISZTINA, FISCHER, JANOS, FELLEGVARI, IREN, LEVAI, SANDOR
Format Patent
LanguageEnglish
French
German
Published 31.10.2001
Edition7
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Summary:PCT No. PCT/HU97/00083 Sec. 371 Date Jul. 27, 1999 Sec. 102(e) Date Jul. 27, 1999 PCT Filed Dec. 15, 1997 PCT Pub. No. WO98/27050 PCT Pub. Date Jun. 25, 1998The present invention relates to a proccss for preparing cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphtalenamine and its acid addition salts wherein N-methyl-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphtalene-1-en]-amine-N-oxide is hydrogenated in an inert solvent in the presence of a catalyst, then the resulting mixture is treated with alcanolic solution of a mineral acid, the resulting cis-racemic acid addition salt is converted to the free base by known methods, resolved and the resulting cis-(+)-base of formula (II) is converted to an acid addition salt. N-methyl-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphtalene-1-en]amine-N-oxide is also disclosed.
Bibliography:Application Number: EP19970951338