NOVEL HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USES THEREOF

A heterocyclic amide compound of the formula (I) wherein each symbol is as delined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof and a pharmaceutical use thereof. The heterocyclic amide compound and a pharmacologically acceptable salt thereof...

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Main Authors SAKASHITA, HIROSHI, EDA, MASAHIRO, AKAHOSHI, FUMIHIKO, ASHIMORI, ATSUYUKI, YOSHIMURA, TAKUYA, NAKAJIMA, MASAHIDE, IMADA, TERUAKI
Format Patent
LanguageEnglish
French
German
Published 02.10.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A heterocyclic amide compound of the formula (I) wherein each symbol is as delined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof and a pharmaceutical use thereof. The heterocyclic amide compound and a pharmacologically acceptable salt thereof of the present invention have superior inhibitory action on chymase group in mammals inclusive of human, and can be administered orally or parenterally. Therefore, they are useful as chymase inhibitors and can be used for the prophylaxis and treatment of various diseases caused by chymase, such as those caused by angiotensin II.
Bibliography:Application Number: EP19970909602