CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE

PCT No. PCT/US97/17784 Sec. 371 Date Sep. 24, 1997 Sec. 102(e) Date Sep. 24, 1997 PCT Filed Sep. 24, 1997 PCT Pub. No. WO98/54133 PCT Pub. Date Dec. 3, 1998Novel chemical analogs of the methadone metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) are disclosed. The derivatives can b...

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Bibliographic Details
Main Authors SIGLER, GERALD, FRANCIS, COTY, WILLIAM, POWELL, MICHAEL, JOSEPH
Format Patent
LanguageEnglish
French
German
Published 17.11.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
TESTING
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Summary:PCT No. PCT/US97/17784 Sec. 371 Date Sep. 24, 1997 Sec. 102(e) Date Sep. 24, 1997 PCT Filed Sep. 24, 1997 PCT Pub. No. WO98/54133 PCT Pub. Date Dec. 3, 1998Novel chemical analogs of the methadone metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) are disclosed. The derivatives can be used for formation of EDDP-protein conjugates. The conjugates can be used in turn to raise antibodies reactive with EDDP and having a low cross-reactivity with methadone. The antibodies and EDDP-enzyme polypeptide conjugates provide the basis for specific immunoassays used in monitoring compliance with methadone treatment.
Bibliography:Application Number: EP19970911614