Process for the alkylation of alkyl- or benzonitrile in the presence of trialkyl amines or phosphines
Preparation of an alpha , alpha -disubstituted benzyl cyanide (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog (II) with an alkylating agent in presence of a base and a tertiary amine or phosphine. Preparation of an alpha , alpha -disubstituted benzyl cyanide of formula...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
18.06.2003
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | Preparation of an alpha , alpha -disubstituted benzyl cyanide (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog (II) with an alkylating agent in presence of a base and a tertiary amine or phosphine. Preparation of an alpha , alpha -disubstituted benzyl cyanide of formula (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog of formula (II) (optionally previously dissolved in an organic solvent) with an alkylating agent of formula R1-X (III) or X-CH2CH2-Z-(CH2)n-X (III') in presence of a base and a tertiary amine or phosphine of formula R7-Q(R8)(R9) (IV). R1 = 1-20C alkyl (optionally substituted by 1-3 Q' or phenyl (itself optionally substituted by 1-3 A or Q')) or 2-20C alkenyl (optionally substituted by 1-3 Q' or phenyl (itself optionally substituted by 1-3 A or Q')); R2 = as R1 or phenyl (optionally substituted by 1-3 Q' A); or R1 + R2 = -CH2CH2-Z-(CH2)n-; R3 = phenyl (optionally substituted by 1-3 A or Q'); R4 = H or as R2; A = 1-6C alkyl; Q' = 3-6C cycloalkyl, OH, ACOO, AO, (1-6C) alkoxy-(1-4C) alkoxy, halo, CF3, CN, NO2, COOH, AOCO, OCH2O, NR5R6CO or NR5R6; R5, R6 = H or A; Z = O, S or NR; R = H, A, benzyl or phenyl; n = 1 or 2; X = halo or 1/2 SO4; R7-R9 = 1-30C alkyl or phenyl; Q = N or P. |
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Bibliography: | Application Number: EP19980123418 |