TRITERPENE DERIVATIVES AND REMEDY FOR LIVER DISEASES

• Main Authors: KUZUHARA, HIROYUKI, SASAKI, KAZUE, NISHIYAMA, SHOJI, MINOWA, NOBUTO
• Format: Patent
• Language: English; French; German
• Published: 22.11.2000
• Edition: 7
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; STEROIDS

A pharmaceutical composition for treating a hepatic disorder, comprising a triterpene derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof is disclosed: wherein R represents a hydroxyl group, alkoxy, alkylcarbonyloxy, or aralkyloxy; R represents alkyl, - CH2OR , wherein R represents a hydrogen atom, alkyl, aralkyl, or alkylcarbonyl, formyl, -COOR , wherein R represents a hydrogen atom or alkyl, or -CH2N(R )R ; or R and R combine with each other to form -O-CR<9)<R )-OCH2-, wherein R and R , which may be the same or different, represent a hydrogen atom, alkyl, or aryl; R and R , which may be the same or different, represent a hydrogen atom, a hydroxyl group, alkyl, hydroxyalkyl, formyl, -COOR , wherein R represents a hydrogen atom or alkyl, or -OR , wherein R represents alkyl, aralkyl, C1-6 alkylcarbonyl, arylcarbonyl, alkenyl, alkenylcarbonyl, or arylalkenylcarbonyl which may be optionally substituted; or R and R combine with each other to form a methylene group; and @ represents a single or double bond, provided that, when @ represents a double bond, R is absent.