Substituted diaminocarboxylic acid

• Main Authors: SCHUDOK, MANFRED, HAASE, BURKHARD, BILLEN, GUENTER, NEISES, BERNHARD, SCHWAB, WILFRIED, THORWART, WERNER
• Format: Patent
• Language: English; French; German
• Published: 12.12.2001
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Phenyl-, thienyl- or furanyl-substituted N( alpha )-sulphonyl-diaminocarboxylic acid derivatives of formula (I) and their stereoisomers and salts are new. R1 = Ar or Het; Ar = phenyl (optionally substituted by 1 or 2 of 1-7C alkyl, 3-7C cycloalkyl, OH, alkyl-COO-, alkyl-O-, alkyl-O-(1-4C alkylene)-O-, halo, CF3, CN, NO2, COOH, alkyl-O-CO-, OCH2O, NR4R5CO and NR4R5); Het = pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thienyl, thiazolyl, oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, indolyl, benzothiophenyl, benzimidazolyl, benzoxazolyl, benzothiazolyl or benzotriazolyl (all optionally substituted as for phenyl in Ar); R2,R4,R5 = H, alkyl, carboxyalkyl, Ar-(CH2)o- or picolyl; or NR4R5 = 4-7 membered ring, optionally having one C replaced by O, S or NH; o = 0-2; R3,G = H, alkyl, 3-6C cycloalkyl, 2-6C alkenyl, Ar-(CH2)m-, Het-(CH2)m-, R6CO-, R6OCO-, R6CH(NH2)CO-, NR7R8CO-, R6SO2-, R6SO2NR7CO-. R'6-NHC(=NR'7)- or a heterocyclic group of formula (i); or N(G)R3 = succinimido, maleimido, 2-oxo-pyrrolidino, 1H-1-pyrrolyl, 1H-1-imidazolyl or 2-oxo-2,3-dihydro-1H-1-pyrrolyl, all monosubstituted by R7; phthalimido or 2-oxo-1-indolinyl, both monosubstituted by R10 in the benzene ring; 1-indolyl; 1-benzimidazolyl; pyrrolidino, piperidino, perhydroazepino or perhydroazocino; or a group of formula (ii)-(vi); one ring C in (iv) is optionally replaced by O, S, SO2 or NR2; m = 0-3; r = 1 or 2; R6 = H, alkyl (optionally substituted as for Ar or by 3-6C cycloalkyl), 3-6C cycloalkyl (optionally substituted as for Ar), 2-6C alkenyl (optionally substituted as for Ar, or by Ar or Het (both optionally having a third substituent as above)); Ar-(CH2)m (in which Ar optionally has a third substituent as above and may further be substituted by OCF3, SO2NH2, NHCOCF3 or benzyl; and (CH2)m is optionally substituted by COOH), naphthyl, adamantyl or Het-(CH2)m-; R7 = H or alkyl; R8 = H, alkyl, Ar-(CH2)m- or Het-(CH2)m-; or NR7R8 = optionally substituted 4-7 membered ring, optionally having one C replaced by O, S or NH; R'6,R'7 = as R6,R7; or alkyl-CO-, NO2 or Ar-(CH2)m-SO2-; W = N, S or O; R10 = one or the optional substituents of Ar; A = direct bond, O, CH=CH or C IDENTICAL C; B = (CH2)m, O(CH2)q or CH=CH; q = 1-5; D = (CH2)s, optionally with one C replaced by optionally substituted NH, O or S; s = 1-6; X = CH=CH, O or S; R9 = H; or can also be alkyl, phenyl, succinimidyl, benzotriazolyl or benzyl if G = H; unless specified otherwise alkyl moieties have 1-6C.