Platinum (IV) complex and pharmaceutical composition comprising the same

A diamine-platinum (IV) complex represented by the following formula (1): wherein R and R together represent R O-CH(CH2NH2)2 (R represents hydrogen, acetyl, trifluoroacetyl, benzoyl, cycloalkylcarbonyl or methanesulfonyl) or a C5-8 1,2-cycloalkanediamine; R and R each represents hydrogen or R CO- (R...

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Bibliographic Details
Main Authors OHTSUKA, MARI, MIZUNO, HIROYUKI, KOYA, HIDEHIKO, MOGI, KINICHI, SATO, SUSUMU
Format Patent
LanguageEnglish
French
German
Published 16.09.1998
Edition6
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A diamine-platinum (IV) complex represented by the following formula (1): wherein R and R together represent R O-CH(CH2NH2)2 (R represents hydrogen, acetyl, trifluoroacetyl, benzoyl, cycloalkylcarbonyl or methanesulfonyl) or a C5-8 1,2-cycloalkanediamine; R and R each represents hydrogen or R CO- (R represents alkyl, halogenoalkyl, cycloalkyl, aryl or aralkyl); and two X's together represent a malonic acid residue or glycolic acid residue which may have a substituent capable of coordinating to the platinum in formula (1) by an O,O-coordination or an N-acylamino acid residue coordinating to the platinum in formula (1) by an O,N-coordination; and a pharmaceutical composition comprising as an active ingredient the above-described diamine-platinum (IV) complex.
Bibliography:Application Number: EP19970122684