Combination of herpes simplex virus and chemotherapy for treating cancer

The present invention is directed to novel methods of enhancing the effectiveness of DNA damaging agents by exposing cells to viruses prior to or during exposure to the damaging agent. In certain embodiments of the invention, the DNA damaging agent is ionizing radiation, the virus is an adenovirus,...

Full description

Saved in:
Bibliographic Details
Main Authors HALLAHAN, Dennis, E, KUFE, Donald, WEICHSELBAUM, Ralph, R, SIBLEY, Gregory, S, ROIZMAN, Bernard
Format Patent
LanguageEnglish
French
German
Published 22.03.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ELECTROTHERAPY
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MAGNETOTHERAPY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
RADIATION THERAPY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
ULTRASOUND THERAPY
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:The present invention is directed to novel methods of enhancing the effectiveness of DNA damaging agents by exposing cells to viruses prior to or during exposure to the damaging agent. In certain embodiments of the invention, the DNA damaging agent is ionizing radiation, the virus is an adenovirus, and the increase in cell killing is synergistic when compared to radiation alone.
Bibliography:Application Number: EP19960934086