HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF

Disclosed are heteroaryl-substituted acryloylguanidine derivatives of formula (I) and their salts. wherein ring A represents a 5-membered or 6-membered heteroaryl group which may optionally be substituted and may optionally be condensed with one or two benzene rings; ring B represents an optionally-...

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Bibliographic Details
Main Authors TAKANASHI, MASAHIRO, YANAGISAWA, ISAO, TOYOSHIMA, AKIRA, OKAZAKI, TOSHIO, KIKUCHI, KAZUMI
Format Patent
LanguageEnglish
French
German
Published 11.11.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are heteroaryl-substituted acryloylguanidine derivatives of formula (I) and their salts. wherein ring A represents a 5-membered or 6-membered heteroaryl group which may optionally be substituted and may optionally be condensed with one or two benzene rings; ring B represents an optionally-substituted aryl group; and R1 represents a hydrogen atom, a halogen atom, or a lower alkyl group optionally substituted by one or more halogen atoms. As acting as an Na<+>/H<+> exchange inhibitor, the derivatives and their salts are useful in medicine, especially in prevention, treatment and diagnosis of various disorders to be caused by the Na<+>/H<+> exchanger, such as hypertension, arrhythmia, angina pectoris, arteriosclerosis, diabetic complications, etc.
Bibliography:Application Number: EP19960931252