RESOLUTION OF 1-AZABICYCLO 2.2.2]OCTAN-3-AMINE, 2-(DIPHENYLMETHYL)-N- 2-METHOXY-5-(1-METHYLETHYL)PHENYL]METHYL

PCT No. PCT/IB96/00648 Sec. 371 Date Dec. 16, 1997 Sec. 102(e) Date Dec. 16, 1997 PCT Filed Jul. 4, 1996 PCT Pub. No. WO97/03984 PCT Pub. Date Feb. 6, 1997A process for resolving 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] in which 1-azabicyclo[...

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Bibliographic Details
Main Authors TICKNER, DEREK, L, MELTZ, MORGAN
Format Patent
LanguageEnglish
French
German
Published 24.09.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/IB96/00648 Sec. 371 Date Dec. 16, 1997 Sec. 102(e) Date Dec. 16, 1997 PCT Filed Jul. 4, 1996 PCT Pub. No. WO97/03984 PCT Pub. Date Feb. 6, 1997A process for resolving 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] in which 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] is reacted with 1R-(-)-10-camphorsulfonic acid in a solvent capable of dissolving both the foregoing reactants and selectively dissolving the camphorsulfonic acid salt of the corresponding (2R, 3R) enantiomer relative to the (2S, 3S) enantiomer.
Bibliography:Application Number: EP19960918801