Substituted tricyclics

This invention provides tricyclic compounds as depicted in the general formula (III) below: wherein; A is phenyl or pyridyl wherein the nitrogen is at the 5-,6-,7- or 8-position; one of B or D is nitrogen and the other is carbon; Z is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1-,...

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Bibliographic Details
Main Authors DILLARD, ROBERT DELANE, BACH, NICHOLAS JAMES, MORIN, JOHN MICHAEL, JR, DRAHEIM, SUSAN ELIZABETH
Format Patent
LanguageEnglish
French
German
Published 09.07.2003
Edition7
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides tricyclic compounds as depicted in the general formula (III) below: wherein; A is phenyl or pyridyl wherein the nitrogen is at the 5-,6-,7- or 8-position; one of B or D is nitrogen and the other is carbon; Z is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1-,2-, or 3-position, or a 6 membered heterocyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-,2-,or 3-position, and nitrogen at the 1-,2-,3- or 4-position, which inhibit sPLA2 mediated release of fatty acids (e.g. arachidonic acid). Such compounds would be of value in general treatment of conditions induced and/or maintained by overproduction of sPLA2 such as septic shock.
Bibliography:Application Number: EP19970308645