BRAIN EDEMA INHIBITOR

The present invention relates to a composition for treating or preventing brain edemas which comprises an endothelin antagonist as an active ingredient, for example, the compound of the following formula (I): or pharmaceutically acceptable salts or hydrates thereof, bosentan, cycloÄD-aspartyl-L-Ä3-(...

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Bibliographic Details
Main Authors NINOMIYA, MITSUYOSHI, MATSUO, YOSHIYUKI
Format Patent
LanguageEnglish
French
German
Published 25.04.2001
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a composition for treating or preventing brain edemas which comprises an endothelin antagonist as an active ingredient, for example, the compound of the following formula (I): or pharmaceutically acceptable salts or hydrates thereof, bosentan, cycloÄD-aspartyl-L-Ä3-(4-phenylpiperazin-1-ylcarbonyl)Ü-alanyl-L-aspar tyl-D-Ä2-(2thienyl)Üglycyl-L-leucyl-D-tryptophylÜdisodium or cyclo ÄD-Asp-L-Pro-D-Val-L-Leu-D-TrpÜ. Furthermore, the present invention provides a method for treating or preventing brain edemas, which comprises administering an effective amount of an endothelin antagonist and use of an endothelin antagonist in the manufacture of a medicament for treating or preventing brain edemas. An endothelin antagonist exhibits an inhibitory effect on all brain edemas regardless of the mechanism of onset and thus is highly useful in the treatment or prevention of brain edemas.
Bibliography:Application Number: EP19960919984