Human Interleukin 12 gene expression regulating sequences
The present invention relates to human interleukin 12 (IL12) gene expression regulating sequences, including the IL-12p35 subunit gene promoter sequence, and the first intron sequence of the human IL-12p40 subunit gene, preferably operably linked to the first exon of the human IL-12p40 subunit gene...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
14.01.1998
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to human interleukin 12 (IL12) gene expression regulating sequences, including the IL-12p35 subunit gene promoter sequence, and the first intron sequence of the human IL-12p40 subunit gene, preferably operably linked to the first exon of the human IL-12p40 subunit gene and further upstream to the human IL-12p40 subunit gene promoter sequence. Further, the invention relates more particularly to DNA constructs containing such a sequence and a reporter gene, to vectors and host cells containing such a DNA construct, to a method of screening for compounds which affect the production of IL-12 in such cells, in particular human cells, to non-proteinaceous compounds obtainable by such a method, and to transgenic non-human mammalian animals which express a reporter gene under the control of one of said IL-12 gene expression regulating sequences. |
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Bibliography: | Application Number: EP19960201977 |