BICYCLIC ISOTHIOUREA DERIVATIVES USEFUL IN THERAPY

There are provided novel compounds of formula I wherein D represents alkyl C1 to 6; T represents a C3-5 saturated or unsaturated alkylene chain substituted by -(CH2)m- NXY; -O-(CH2)z-NH- substituted by -(CH2)m-NXY; or -U-(CH2)a-N(X)-(CH2)b-; and a, b, m, X and Y are as defined in the specification t...

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Bibliographic Details
Main Author MACDONALD, JAMES, EDWIN
Format Patent
LanguageEnglish
French
German
Published 12.01.2000
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:There are provided novel compounds of formula I wherein D represents alkyl C1 to 6; T represents a C3-5 saturated or unsaturated alkylene chain substituted by -(CH2)m- NXY; -O-(CH2)z-NH- substituted by -(CH2)m-NXY; or -U-(CH2)a-N(X)-(CH2)b-; and a, b, m, X and Y are as defined in the specification together with processes for their preparation, compositions containing them and their use in therapy. Compounds of formula I are expected to be useful inter alia in the treatment of neurodegenerative disorders.
Bibliography:Application Number: EP19960903295