AFFINITY SELECTION OF LIGANDS BY MASS SPECTROSCOPY

Compounds are quickly selected from a combinatorial library by contacting the library with a target (e.g., receptor), separating non-binding compounds from compound-target complexes, and analyzing the complexes or eluted compound by mass spectroscopy. SAR information is obtained by performing this s...

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Bibliographic Details
Main Authors HUEBNER, VERENA, D, DOLLINGER, GAVIN, D
Format Patent
LanguageEnglish
French
German
Published 05.11.1997
Edition6
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:Compounds are quickly selected from a combinatorial library by contacting the library with a target (e.g., receptor), separating non-binding compounds from compound-target complexes, and analyzing the complexes or eluted compound by mass spectroscopy. SAR information is obtained by performing this selection at two or more different ratios of compound to target.
Bibliography:Application Number: EP19960906169