PROCESS FOR PRODUCING 3-(AMINOMETHYL)-6-CHLOROPYRIDINES

The present invention is directed to methods for manufacturing 3-(aminomethyl)-6-chloropyridines represented by a general formula ÄIIÜ; wherein R represents hydrogen or a lower alkyl and R represents hydrogen, a lower alkyl or an halogen atom, characterized in that the compound represented by the ge...

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Bibliographic Details
Main Authors IMAGAWA, TSUTOMU, INOUE, TSUTOMU, HATANAKA, KAZUHIRO, TAKAHASHI, JUN
Format Patent
LanguageEnglish
French
German
Published 27.08.1997
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is directed to methods for manufacturing 3-(aminomethyl)-6-chloropyridines represented by a general formula ÄIIÜ; wherein R represents hydrogen or a lower alkyl and R represents hydrogen, a lower alkyl or an halogen atom, characterized in that the compound represented by the general formula ÄIIÜ is manufactured by allowing 3-(substituted-aminomethyl)pyridine 1-oxide represented by a general formula ÄIÜ; wherein R represents alkyl, aryl, aralkyl or alkoxy, R and R are as described above, to react with a base represented by a general formula ÄaÜ; R' R'' R''' N wherein R', R'' and R''' may be the same or different one another and represent each independently a lower alkyl or an aromatic group, or R', R'', R''' and N may form together an optionally-substituted pyridine ring, in the presence of an electrophilic reagent having at least one chlorine atom, and subsequently treating the reaction product with hydrogen chloride and water. The compounds manufactured according to the present invention are useful as the raw materials used for the manufacturing of agricultural chemicals and pharmaceuticals, and particularly useful for the raw materials for manufacturing insecticides.
Bibliography:Application Number: EP19960929543