AZAASPARTIC ACID ANALOGS AS INTERLEUKIN-1 BETA CONVERTING ENZYME INHIBITORS

Disclosed are compounds, compositions and methods for inhibiting interleukinprotease activity. The compounds, alpha -substituted acetamides a (A) wherein: R2=H or alkyl; R3=halo, O(CO)0-1 aryl, OPOR4R5; where R4 and R5=aryl; R6=H, aryl or aralkyl; R7=independently selected from R6, CF3 and CF2CF3; R...

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Bibliographic Details
Main Authors DOLLE, ROLAND E, GRAYBILL, TODD L
Format Patent
LanguageEnglish
French
German
Published 10.06.1998
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are compounds, compositions and methods for inhibiting interleukinprotease activity. The compounds, alpha -substituted acetamides a (A) wherein: R2=H or alkyl; R3=halo, O(CO)0-1 aryl, OPOR4R5; where R4 and R5=aryl; R6=H, aryl or aralkyl; R7=independently selected from R6, CF3 and CF2CF3; R1=R6-CO, heteroaryl-CO, heteroaralkyl-CO and amino acid.
Bibliography:Application Number: EP19950928696