METHOD FOR THE PREPARATION OF GLYCOPEPTIDIC ANTIBIOTIC PRECURSORS BY INTRAMOLECULAR CYCLISATION AND FORMATION OF A BIARYL ETHER BRIDGE AND NOVEL COMPOUNDS SO OBTAINED

• Main Authors: BOISOUSSY, MICHELE, CHASTANET, JACQUELINE, BEUGELMANS, RENE, ZHU, JIE PING
• Format: Patent
• Language: English; French; German
• Published: 11.12.1996
• Edition: 6
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Novel method for intermolecular cyclization by formation of a biaryl ether bridge through the reaction as shown above. In formulas (I) and (II) R1 is a nitro radical adjacent to the oxygen bridge, Hal is a fluoride or chlorine atom, R2, R3 and R4 together form a peptidic chain, in the presence of a...