METHOD FOR THE PREPARATION OF GLYCOPEPTIDIC ANTIBIOTIC PRECURSORS BY INTRAMOLECULAR CYCLISATION AND FORMATION OF A BIARYL ETHER BRIDGE AND NOVEL COMPOUNDS SO OBTAINED

Novel method for intermolecular cyclization by formation of a biaryl ether bridge through the reaction as shown above. In formulas (I) and (II) R1 is a nitro radical adjacent to the oxygen bridge, Hal is a fluoride or chlorine atom, R2, R3 and R4 together form a peptidic chain, in the presence of a...

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Bibliographic Details
Main Authors BOISOUSSY, MICHELE, CHASTANET, JACQUELINE, BEUGELMANS, RENE, ZHU, JIE PING
Format Patent
LanguageEnglish
French
German
Published 11.12.1996
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel method for intermolecular cyclization by formation of a biaryl ether bridge through the reaction as shown above. In formulas (I) and (II) R1 is a nitro radical adjacent to the oxygen bridge, Hal is a fluoride or chlorine atom, R2, R3 and R4 together form a peptidic chain, in the presence of a weak phase in a heterogeneous medium. The invention also concerns compounds of formulas (I) and (II) and the use of compounds of formula (I) to obtain useful compounds.
Bibliography:Application Number: EP19950909846