Dialysis filter/reactor for capturing endotoxins, and relative fabrication method

A dialysis filter/reactor including at least a hollow fiber made of ultrafiltering cellulose-based material and inside which polymyxin is immobilized; the polymyxin being covalently bonded to the cellulose fiber by activation prior to immobilization and using sodium periodate as an oxidant, and by s...

Full description

Saved in:
Bibliographic Details
Main Authors TETTA, CIRO, GERVASIO, RENZO, WRATTEN, MARY LOU
Format Patent
LanguageEnglish
French
German
Published 20.11.1996
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SEPARATION
TRANSPORTING
Online AccessGet full text

Cover

More Information
Summary:A dialysis filter/reactor including at least a hollow fiber made of ultrafiltering cellulose-based material and inside which polymyxin is immobilized; the polymyxin being covalently bonded to the cellulose fiber by activation prior to immobilization and using sodium periodate as an oxidant, and by stabilization subsequent to immobilization and using sodium borohydride as a reducer; the activating step being performed for a relatively long period of time (1.5 h) with a low concentration (2.5 gr/l) of sodium periodate, and by circulating an aqueous solution of sodium periodate inside the fibers of the filter at a very high specific flow rate (1500 mm /minute/mm ).
Bibliography:Application Number: EP19960107794