SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS

This invention is directed to compounds of formula (I), wherein R is an optionally substituted lower alkyl group; R is an optionally substituted oxaaliphatic group; R is an optionally substituted aryl group or an optionally substituted heteroaryl group; Q , Q and Q are independently nitrogen, CX or...

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Bibliographic Details
Main Authors FENTON, GARRY, THURAIRATNAM, SUKANTHINI, PALFREYMAN, MALCOLM N
Format Patent
LanguageEnglish
French
German
Published 01.04.1998
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention is directed to compounds of formula (I), wherein R is an optionally substituted lower alkyl group; R is an optionally substituted oxaaliphatic group; R is an optionally substituted aryl group or an optionally substituted heteroaryl group; Q , Q and Q are independently nitrogen, CX or CH; Z is oxygen or sulfur; Z is -CH=CH-, -CC-, -CH2-CZ-, -CZCH2-, -CZ-CZ-, -CH2-NH-, -CH2-O-, -CH2-S-, -CX2-O-, -CZNH-, -NH-CH2-, -O-CH2_, -SCH2-, -SOCH2-, -SO2CH2-, -O-CX2-, -O-CZ-, -NH-CZ-, -N=N-, -NH-SO2-, -SO2-NH-, -CZ-CZ-NH-, -NH-CO-O-, -O-CO-NH- or -NH-CO-NH-; Z is oxygen or sulfur; and X is halo; or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which possess useful pharmaceutical properties. They are especially useful for inhibiting the production or physiological effects of TNF and inhibit cyclic AMP. The present invention is also directed to their pharmaceutical use, pharmaceutical compositions containing the compounds, and methods for their preparation.
Bibliography:Application Number: EP19950906437