PHENYLMETHYL HEXANAMIDES, AND THE USE THEREOF

• Main Author: DAINES, ROBERT, A
• Format: Patent
• Language: English; French; German
• Published: 30.06.1999
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention is to compounds of formula (I) or formula (II) or pharmaceutically acceptable salts thereof for the treatment of PKC-mediated disease states, wherein inter alia R is hydrogen, lower alkyl or optionally substituted aryl; R is hydrogen or lower alkyl; R is hydrogen or -(CH2)kR , wherein R is -CO2R , -NHC(O)R , -NR R , or -C(O)NR R , wherein R and R , independently from one another, are hydrogen, or alkyl provided that when R is -CO2R , R is not hydrogen; R and R , independently from one another, are hydrogen or lower alkyl, or wherein R and R , together with the nitrogen to which they are bound, form a saturated or unsaturated 5-, 6-, or 7-membered ring; E is CH-R , wherein R is hydrogen, alkoxy, -OH or -NR R , wherein R and R , independently from one another, are hydrogen or lower alkyl, or wherein R and R , together with the nitrogen to which they are bound, form a saturated or unsaturated 5-, 6-, or 7-membered ring; X is CH or N; Y is -CH2 or -O, and further wherein Y is positioned on the central aromatic ring either ortho, meta or para relative to the amine containing side chain; Z is -CH2 or optionally substituted aryl; k is an integer between 0 and 10; m is an integer between 0 and 10, provided that m is 0 only when Z is optionally substituted aryl or optionally substituted heteroaryl, and further, provided that when m is 0 and Z is optionally substituted aryl or optionally substituted heteroaryl, R and R are not hydrogen or lower alkyl; n is an integer between 6 and 20; and p is an integer between 0 and 1, provided that p must be 0 when Z is optionally substituted aryl or optionally substituted heteroaryl.