NOVEL IMIDAZOLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

The invention relates to the imidazole derivatives as selective antagonistic substances against muscarinic acetylcholine and provides imidazole derivatives represented by a general formula (1) or (2) Äwherein R1 is a phenyl group which may have substituent or thienyl group, R2 is a cyano group, a ca...

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Bibliographic Details
Main Authors OKAZAKI, KEI, KIYOTA, HIROMI, SEGAWA, MITSURU, MIYACHI, HIROYUKI
Format Patent
LanguageEnglish
French
German
Published 15.05.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to the imidazole derivatives as selective antagonistic substances against muscarinic acetylcholine and provides imidazole derivatives represented by a general formula (1) or (2) Äwherein R1 is a phenyl group which may have substituent or thienyl group, R2 is a cyano group, a carboxy group, CONR7R8 group (wherein R7 and R8 each independently represent hydrogen atom or lower alkyl group, or R7and R8 may form a ring by alkylene chain which may contain hetero atom) or COOR9 group (wherein R9 is a lower alkyl group), R3 is a hydrogen atom or lower alkyl group, R4, R5 and R6 each independently represent hydrogen atom, lower alkyl group which may have substituent or cycloalkyl groups, or may form a condensed ring at the positions of R5 and R6 with benzene ring, R10 is a lower alkyl group or aralkyl group which may have substituent, m is an integer from 1 to 6, and Z is a halogen atomÜ.
Bibliography:Application Number: EP19950902285