USE OF AN AGENT WHICH MODULATES TYROSINE PHOSPHORYLATION FOR MODULATING THE PERMEABILITY OF A PSYCHOLOGICAL BARRIER
Permeability of the blood-brain barrier and other physiological barriers can be modulated by the degree of tyrosine phosphorylation of proteins. Agents which promote tyrosine protein dephosphorylation reduce the permeability of the blood-brain barrier and those which promote phosphorylation increase...
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Main Authors | , , , |
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Format | Patent |
Language | English French German |
Published |
28.08.1996
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | Permeability of the blood-brain barrier and other physiological barriers can be modulated by the degree of tyrosine phosphorylation of proteins. Agents which promote tyrosine protein dephosphorylation reduce the permeability of the blood-brain barrier and those which promote phosphorylation increase permeability. Increasing blood-brain barrier permeability is useful in delivering drugs having a desired effect upon the central nervous system; decreasing blood-brain barrier permeability and other physiological barrier permeability is useful in preventing undesired compounds reaching the CNS and in certain clinical conditions. |
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Bibliography: | Application Number: EP19950901509 |