Carboxyalkyl heterocyclic derivatives
A compound is provided represented by the following general formula (A) wherein two of Ra, Rb and Rc are oxygen; X is a kind of benzyl, a kind of benzothiazolylmethyl, or a kind of naphthylmethyl; R is hydrogen or lower alkyl; n is an integer of 1 to 3; and Z indicates a direct bond or a bridging mo...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French German |
| Published |
17.04.2002
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| Edition | 7 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A compound is provided represented by the following general formula (A) wherein two of Ra, Rb and Rc are oxygen; X is a kind of benzyl, a kind of benzothiazolylmethyl, or a kind of naphthylmethyl; R is hydrogen or lower alkyl; n is an integer of 1 to 3; and Z indicates a direct bond or a bridging moiety containing one carbon atom. The compounds act as selective inhibitors of aldose reductase. The compounds provided are useful as drugs for therapy and prevention of various types of diabetic complications. |
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| AbstractList | A compound is provided represented by the following general formula (A) wherein two of Ra, Rb and Rc are oxygen; X is a kind of benzyl, a kind of benzothiazolylmethyl, or a kind of naphthylmethyl; R is hydrogen or lower alkyl; n is an integer of 1 to 3; and Z indicates a direct bond or a bridging moiety containing one carbon atom. The compounds act as selective inhibitors of aldose reductase. The compounds provided are useful as drugs for therapy and prevention of various types of diabetic complications. |
| Author | OKAMOTO, KAORU NAGAKI, YASUHIRO KOTANI, TAKAYUKI |
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| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | Heterocyclische Carboxyalkylderivate Dérivés carboxyalcoyle hétérocycliques |
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| Notes | Application Number: EP19950120208 |
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| RelatedCompanies | NIPPON ZOKI PHARMACEUTICAL CO., LTD |
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| Snippet | A compound is provided represented by the following general formula (A) wherein two of Ra, Rb and Rc are oxygen; X is a kind of benzyl, a kind of... |
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| Title | Carboxyalkyl heterocyclic derivatives |
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