Carboxyalkyl heterocyclic derivatives

A compound is provided represented by the following general formula (A) wherein two of Ra, Rb and Rc are oxygen; X is a kind of benzyl, a kind of benzothiazolylmethyl, or a kind of naphthylmethyl; R is hydrogen or lower alkyl; n is an integer of 1 to 3; and Z indicates a direct bond or a bridging mo...

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Bibliographic Details
Main Authors KOTANI, TAKAYUKI, NAGAKI, YASUHIRO, OKAMOTO, KAORU
Format Patent
LanguageEnglish
French
German
Published 17.04.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A compound is provided represented by the following general formula (A) wherein two of Ra, Rb and Rc are oxygen; X is a kind of benzyl, a kind of benzothiazolylmethyl, or a kind of naphthylmethyl; R is hydrogen or lower alkyl; n is an integer of 1 to 3; and Z indicates a direct bond or a bridging moiety containing one carbon atom. The compounds act as selective inhibitors of aldose reductase. The compounds provided are useful as drugs for therapy and prevention of various types of diabetic complications.
Bibliography:Application Number: EP19950120208