Use of 5-Thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo compounds in antitumor therapy
The present invention relates to the use of 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo compounds of the general formula I, wherein the radicals have the following meanings: R is hydrogen, halogen, R is hydrogen, halogen, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCOC6H4CONH, 3-o-chlorophen...
Saved in:
Main Authors | , , , , , , , |
---|---|
Format | Patent |
Language | English French German |
Published |
18.03.1998
|
Edition | 6 |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The present invention relates to the use of 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo compounds of the general formula I, wherein the radicals have the following meanings: R is hydrogen, halogen, R is hydrogen, halogen, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCOC6H4CONH, 3-o-chlorophenyl-5-methyl-isoxazolyl-4-carbonyl amino, R is hydrogen, alkyl, benzyl, a heterocyclic ring e.g. isoxazole, pyrazole, n is 1 or 2. In the application examples of the suppression of uterine cervix carcinoma cells (HeLa) by the use of various substituted 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo derivatives are disclosed. |
---|---|
AbstractList | The present invention relates to the use of 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo compounds of the general formula I, wherein the radicals have the following meanings: R is hydrogen, halogen, R is hydrogen, halogen, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCOC6H4CONH, 3-o-chlorophenyl-5-methyl-isoxazolyl-4-carbonyl amino, R is hydrogen, alkyl, benzyl, a heterocyclic ring e.g. isoxazole, pyrazole, n is 1 or 2. In the application examples of the suppression of uterine cervix carcinoma cells (HeLa) by the use of various substituted 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo derivatives are disclosed. |
Author | GRDISA, MIRA, D. SC LUKIC, IRENA, M. SC HERAK, JURE J., D. SC KOVACEVIC, MICE, D. SC TOMIC, MIRJANA M. SC HORVATIC, MARJETA, M. SC MANDIC, ZORA M. SC PAVELIC, KRESIMIR, D. SC |
Author_xml | – fullname: HORVATIC, MARJETA, M. SC – fullname: TOMIC, MIRJANA M. SC – fullname: MANDIC, ZORA M. SC – fullname: GRDISA, MIRA, D. SC – fullname: LUKIC, IRENA, M. SC – fullname: KOVACEVIC, MICE, D. SC – fullname: PAVELIC, KRESIMIR, D. SC – fullname: HERAK, JURE J., D. SC |
BookMark | eNqNyjsOgkAQgGEKLXzdYQ7AkkUeWmswlhZoYwwZlyFsAjsbdknE02vhAaz-4vuXwcywoUVwuzoCbiATZatRxGEqao1vfGo1qY7hnkbbSD6AlUdDIgn3X-cXg-Le8mhqB9oAGq_92PMAvqUB7bQO5g12jja_rgI4FeXxLMhyRc6iIkO-Ki5yJ7Nc5oc4-WP5ADXSOB8 |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | Verwendung von 5-Thia-1,4-Diazabicyclo [4.2.0] Octane-3,8-dioxo Verbindungen in der Antitumor-Therapie Utilisation de composés 5-thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo dans la thérapie antitumorale |
Edition | 6 |
ExternalDocumentID | EP0705606B1 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_EP0705606B13 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 14:24:41 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English French German |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_EP0705606B13 |
Notes | Application Number: EP19950114673 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980318&DB=EPODOC&CC=EP&NR=0705606B1 |
ParticipantIDs | epo_espacenet_EP0705606B1 |
PublicationCentury | 1900 |
PublicationDate | 19980318 |
PublicationDateYYYYMMDD | 1998-03-18 |
PublicationDate_xml | – month: 03 year: 1998 text: 19980318 day: 18 |
PublicationDecade | 1990 |
PublicationYear | 1998 |
RelatedCompanies | PLIVA, FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA DIONICKO DRUSTVO |
RelatedCompanies_xml | – name: PLIVA, FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA DIONICKO DRUSTVO |
Score | 2.472403 |
Snippet | The present invention relates to the use of 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo compounds of the general formula I, wherein the radicals have the... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | Use of 5-Thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo compounds in antitumor therapy |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980318&DB=EPODOC&locale=&CC=EP&NR=0705606B1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_GFPVNp-L8Ig_Sp2WuS7u2D0NY2zEEtyHbGIiMrkmxoM1YO3T-9V7qOn3Rt5CDkFxyuV8-fncAN0Fk8shqhhSxbUgNxjl1DMeiAl2n2eTMdEQe7bPf6o2N-6k5LUFccGHyOKHveXBEtKgQ7T3L9-vFzyWWl_-tTG_nMVbJu-6o7Wm8oIupNap5nbY_HHgDV3NdLGn9xzaubPTtrQ4elHYUilZh9v1JR5FSFr89SvcQdofYWJIdQUkkFdh3i8RrFdh72Lx3Y3FjeukxTMapIDIiJh29xAHVawbFqf0M5nG4Dl8leTLqzXrjmcgQ4Z6grGajXH5Ioj6Nq9xJKYkTEihW7upNLsk38Wp9AqTrj9wexQ7OtsqY-cPtUNgplBOZiDMgum7xFuoW4VDDiBzb5pYVMo7YhrHAbvAqVP9s5vwf2QUcFCQ83b6EcrZciSv0wtn8OtffF1peihE |
link.rule.ids | 230,309,786,891,25594,76906 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEL8QNOKbokb87IPZE0XGNrY9EBM2CCpfMYOQGEPGuoUluhI2ovjXe50MfdG3ppc07bXX-_Xjdwdw4wYaC_SaRxHbelRVGKOmaurUR9ep1ZiimX4a7bNf74zUh4k2yUGYcWHSOKHvaXBEtCgP7T1J9-vFzyWWnf6tjG9nIVbxu7bTsCWW0cXEGpXsZqM1HNgDS7IsLEn9pwaubPTt9SYelHZ0EZxXIKdxU5BSFr89SvsAdofYWJQcQs6PilCwssRrRdjrbd67sbgxvfgIxqPYJzwgGnXmoUvlskpxaj_dWeitvVdOntVKrVJ9IdxDuOdTpWygnH9wIj6Ni9xJMQkj4gpW7uqNL8k38Wp9DKTdcqwOxQ5Ot8qYtobboSgnkI945J8CkWWd1VG3CIeqamAaBtN1T2GIbRTFNaqsBKU_mzn7R3YNhY7T60679_3Hc9jPCHmycQH5ZLnyL9EjJ7OrVJdf90WM_g |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Use+of+5-Thia-1%2C4-diazabicyclo+%5B4.2.0%5D+octane-3%2C8-dioxo+compounds+in+antitumor+therapy&rft.inventor=HORVATIC%2C+MARJETA%2C+M.+SC&rft.inventor=TOMIC%2C+MIRJANA+M.+SC&rft.inventor=MANDIC%2C+ZORA+M.+SC&rft.inventor=GRDISA%2C+MIRA%2C+D.+SC&rft.inventor=LUKIC%2C+IRENA%2C+M.+SC&rft.inventor=KOVACEVIC%2C+MICE%2C+D.+SC&rft.inventor=PAVELIC%2C+KRESIMIR%2C+D.+SC&rft.inventor=HERAK%2C+JURE+J.%2C+D.+SC&rft.date=1998-03-18&rft.externalDBID=B1&rft.externalDocID=EP0705606B1 |