Use of 5-Thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo compounds in antitumor therapy

The present invention relates to the use of 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo compounds of the general formula I, wherein the radicals have the following meanings: R is hydrogen, halogen, R is hydrogen, halogen, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCOC6H4CONH, 3-o-chlorophen...

Full description

Saved in:
Bibliographic Details
Main Authors HORVATIC, MARJETA, M. SC, TOMIC, MIRJANA M. SC, MANDIC, ZORA M. SC, GRDISA, MIRA, D. SC, LUKIC, IRENA, M. SC, KOVACEVIC, MICE, D. SC, PAVELIC, KRESIMIR, D. SC, HERAK, JURE J., D. SC
Format Patent
LanguageEnglish
French
German
Published 18.03.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to the use of 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo compounds of the general formula I, wherein the radicals have the following meanings: R is hydrogen, halogen, R is hydrogen, halogen, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCOC6H4CONH, 3-o-chlorophenyl-5-methyl-isoxazolyl-4-carbonyl amino, R is hydrogen, alkyl, benzyl, a heterocyclic ring e.g. isoxazole, pyrazole, n is 1 or 2. In the application examples of the suppression of uterine cervix carcinoma cells (HeLa) by the use of various substituted 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo derivatives are disclosed.
Bibliography:Application Number: EP19950114673