Use of 5-Thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo compounds in antitumor therapy
The present invention relates to the use of 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo compounds of the general formula I, wherein the radicals have the following meanings: R is hydrogen, halogen, R is hydrogen, halogen, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCOC6H4CONH, 3-o-chlorophen...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English French German |
Published |
18.03.1998
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to the use of 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo compounds of the general formula I, wherein the radicals have the following meanings: R is hydrogen, halogen, R is hydrogen, halogen, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCOC6H4CONH, 3-o-chlorophenyl-5-methyl-isoxazolyl-4-carbonyl amino, R is hydrogen, alkyl, benzyl, a heterocyclic ring e.g. isoxazole, pyrazole, n is 1 or 2. In the application examples of the suppression of uterine cervix carcinoma cells (HeLa) by the use of various substituted 5-thia-1,4-diazabicycloÄ4.2.0Üoctane-3,8-dioxo derivatives are disclosed. |
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Bibliography: | Application Number: EP19950114673 |