HEART FAILURE REMEDY

A cardiotonic containing a compound represented by general formula (I) or, if any, a pharmaceutically acceptable salt thereof as the active ingredient, wherein X and X are absent or each represents oxygen; A represents OH or C1-C4 acyloxy; B represents hydrogen or is combined with A to form a bond;...

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Main Authors KAMIKAWAJI, YOSHIMASA, NISSAN ICAL INDUST. LTD, YAMASHITA, TORU, NISSAN ICAL INDUSTRIES, LTD, SETO, KIYOTOMO, NISSAN ICAL INDUSTRIES, LTD, OHRAI, KAZUHIKO, NISSAN ICAL INDUSTRIES, LTD, MASUDA, YUKINORI, NISSAN ICAL INDUSTRIES, LTD, MATSUMOTO, HIROO, NISSAN ICAL INDUSTRIES, LTD
Format Patent
LanguageEnglish
French
German
Published 24.01.1996
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A cardiotonic containing a compound represented by general formula (I) or, if any, a pharmaceutically acceptable salt thereof as the active ingredient, wherein X and X are absent or each represents oxygen; A represents OH or C1-C4 acyloxy; B represents hydrogen or is combined with A to form a bond; X represents oxygen, nitrogen, sulfur, etc.; R and R represent each hydrogen, C1 - C4 alkyl, etc.; and R and R represent each hydrogen, C1 - C4 alkyl, etc., or they may be combined together to represent 1,4-butylene, 1,5-pentylene, etc. The compound has potent activities of increasing cardiac contractility and reducing cardiac rate and is lowly toxic, thus being useful as a cardiotonic.
Bibliography:Application Number: EP19940910589