INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY

• Main Authors: SONESSON, CLAS, AKE, SVENSSON, KJELL, ANDERS, IVAN, STJERNLOF, NILS, PETER, CARLSSON, PER, ARVID, EMIL, HAADSMA-SVENSSON, SUSANNE, R, WATERS, ROSS, NICHOLAS, ANDERSSON, BENGT, RONNY, HANSSON, LARS, OLOV
• Format: Patent
• Language: English; French; German
• Published: 10.01.1996
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PCT No. PCT/US94/02800 Sec. 371 Date Sep. 7, 1995 Sec. 102(e) Date Sep. 7, 1995 PCT Filed Mar. 21, 1994 PCT Pub. No. WO94/21608 PCT Pub. Date Sep. 29, 1994A compound of formula (I) and pharmaceutically acceptable salts thereof, where Z is R3 and X and Y form (a), or X is R3 and Y and Z form (a) or (b); R1 and R2 are independently hydrogen, C1-6 alkyl, C3-7 cycloalkyl, -CH2-C3-7 cycloalkyl, phenyl (optionally substituted with halogen or C1-6 alkyl), -thiophenyl (optionally substituted with halogen or C1-6 alkyl), or C1-6 alkyl phenyl; R3 are independently hydrogen, halogen, -O-C1-6 alkyl or C1-6 alkyl; R4 is a valence bond, CH2 or oxygen; R5 and R6 are independently hydrogen, sulfur, -S-C1-6 alkyl, halogen, CON(R3)2, -COCF3, -CO-C1-6 alkyl, -CO phenyl, oxygen, -CHO, CN except that when Y and Z form (b), R1 and R2 are hydrogen or a C1-6 alkyl and R3 is hydrogen, then at least one of R5 and R6 must be other than hydrogen. These compounds and derivatives thereof exhibit dopamine-receptor stimulating activity in mammals. (I) (a) (b)