METAL-INTERFERON-ALPHA CRYSTALS
The present invention provides for crystalline zinc-interferon alfa-2 (IFN alpha -2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN alpha -2, crystalline calcium-IFN alpha -2, and crystalline IFN alpha -2 having a serum half-life of at least about 1...
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Main Authors | , , , , , |
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Format | Patent |
Language | English French German |
Published |
13.12.1995
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides for crystalline zinc-interferon alfa-2 (IFN alpha -2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN alpha -2, crystalline calcium-IFN alpha -2, and crystalline IFN alpha -2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN alpha -2 comprising forming a soluble metal-IFN alpha -2 complex, and equilibrating the soluble metal-IFN alpha -2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN alpha -2 solution to become supersaturated and form crystalline metal-IFN alpha -2. The present invention also includes crystalline metal-alfa interferon having monoclinic, plate and needle morphologies. |
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Bibliography: | Application Number: EP19940910703 |