Substituted cyclic amine compounds as 5HT2 antagonists

A substituted cyclic amine compound represented by the following general formula (1) wherein each of R to R represents a hydrogen atom, a hydroxyl group, an alkyl group or the like, D represents a methine moiety, a nitrogen atom or the like, P represents -CR (R )- or -NR -, Q represents a methine mo...

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Main Authors TAKAHASHI, ATSUO, SATO, HIROYASU, MANOME, YOICHI, SATO, ISAMU, GENGYOU, KAORU, KOGI, KENTARO, YAMAGUCHI, TAKAHIRO, ISHIGAMI, SACHIKO, YAMADA, SHIN-ICHI, NARITA, SEN-ICHI, SHIMANUKI, EIJI, NISHIMATA, TOYOKI, AOKI, TSUYOSHI
Format Patent
LanguageEnglish
French
German
Published 05.07.1995
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A substituted cyclic amine compound represented by the following general formula (1) wherein each of R to R represents a hydrogen atom, a hydroxyl group, an alkyl group or the like, D represents a methine moiety, a nitrogen atom or the like, P represents -CR (R )- or -NR -, Q represents a methine moiety or a nitrogen atom, each of T and B is a single bond or represents a methylene moiety, a carbonyl group or the like, n is an integer of 1 to 6 and each of R , R and R represents a hydrogen atom, an alkyl group or the like; and synthetic intermediates thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripherol circulatory disease and the like.
Bibliography:Application Number: EP19940120698