PROCESS FOR PREPARING 1,3-DIOXOLANE DERIVATIVES

This invention provides an improved process for the preparation of compounds of formula (I): (I) wherein: n is 0, 1 or 2; each R1 is independently halo or lower alkyl; R2 is nitro or -N(R3)R4 where R3 is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl, lower alkylsulfonyl or -C(Y)R5 where Y is...

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Bibliographic Details
Main Authors GARDNER, JOHN, O, DYSON, NORMAN, H, KERTESZ, DENIS, J, PRINCE, ANTHONY
Format Patent
LanguageEnglish
French
German
Published 26.04.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:This invention provides an improved process for the preparation of compounds of formula (I): (I) wherein: n is 0, 1 or 2; each R1 is independently halo or lower alkyl; R2 is nitro or -N(R3)R4 where R3 is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl, lower alkylsulfonyl or -C(Y)R5 where Y is oxygen or sulfur and R5 is hydrogen, lower alkyl, lower alkoxy or -N(R6)R7 where R6 is hydrogen or lower alkyl and R7 is hydrogen, lower alkyl or lower alkoxycarbonyl; or R3 and R4 together with N is pyrrolidino, piperidino, morpholino, thiomorpholino or piperazino, wherein the piperazino is optionally substituted at the 4-position by -C(O)R8 where R8 is hydrogen, lower alkyl, lower alkoxy or amino; or pharmaceutically acceptable salts thereof. These compounds are useful in treating disease-states characterized by hypercholesterolemia.
Bibliography:Application Number: EP19930915331