2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS

PCT No. PCT/EP94/00529 Sec. 371 Date Nov. 4, 1994 Sec. 102(e) Date Nov. 4, 1994 PCT Filed Feb. 24, 1994 PCT Pub. No. WO94/20504 PCT Pub. Date Sep. 15, 1994The present invention provides cephalosporin sulphones of formula (I) and the pharmaceutically and veterinarily acceptable salts thereof: (I) whe...

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Main Authors ALPEGIANI, MARCO, BISSOLINO, PIERLUIGI, PERRONE, ETTORE
Format Patent
LanguageEnglish
French
German
Published 26.05.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/EP94/00529 Sec. 371 Date Nov. 4, 1994 Sec. 102(e) Date Nov. 4, 1994 PCT Filed Feb. 24, 1994 PCT Pub. No. WO94/20504 PCT Pub. Date Sep. 15, 1994The present invention provides cephalosporin sulphones of formula (I) and the pharmaceutically and veterinarily acceptable salts thereof: (I) wherein n is one or two: A and B are both or each independently hydrogen or an organic radical; R1 represents halogen, A, OA, -S(O)mA wherein m is 0-2, -OC(O)A, -OS(O)2A, -NHC(O)A or -NH-Z wherein Z is a mono, di- or tripeptide and A is as defined above; R2 represents a halogen, A, -S(O)mA, -O-A, -C(O)A, -C(O)OA, -CH2-OA, -CH2S(O)mA, -CH2OC(O)A, -CH2O-Z, -CH2SC(O) A, -CH2-N(A)A, -CH2N+(A)(A')A'', -CH2NH-C(O)A or -CH2NH-Z wherein A and Z are as defined above. The compounds of formula (I) and their salts are elastase inhibitors.
Bibliography:Application Number: EP19940909042