Novel cephalosporin antibiotics and processes for preparation thereof

• Main Authors: LEE, TAE HEE, KIM, SAM SIK, KIM, SUNG IL, WOO, YOUNG MIN, JEON, JAE HOON, KIM, SE HO, LEE, JAE WON, YANG, DUK HO, KIM, YONG ZU, SEO, MI KYEONG, BANG, CHAN SIK, YEO, JAE HONG, LIM, JONG CHAN, OH, HUN SEUNG
• Format: Patent
• Language: English; French; German
• Published: 25.01.1995
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a cephalosporin compound represented by the following general formula (I), its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, hydrate or solvate, or isomers thereof, which is useful as an antibiotic agent : in which R represents hydrogen or an amino-protecting group, R and R can be identical or different and each represent hydrogen or a hydroxy-protecting group, or R and R together can form a diol-protecting cyclic group, R represents hydrogen or a carboxyl-protecting group, R represents hydrogen, C1-4 alkyl, alkoxycarbonyl, carboxyl or sulfomethyl, R represents hydrogen, amino or substituted amino, and R represents C1-4 alkyl, amino or substituted amino, or R and R together with the carbon atoms to which they are attached can form a 3 to 7-membered cyclic group, or R and R together with the carbon and nitrogen atoms to which they are attached can form a 3 to 7-membered heterocyclic ring which may optionally contain additional heteroatoms such as nitrogen and/or oxygen and which may be substituted with the substituents selected from C1-4 alkyl, amino and substituted amino, and Q represents CH or N.