IMMUNOSTIMULATORY AGENT

• Main Authors: TAKASE, MITSUNORI 138-10, MINAMI-NAKAMARU, BELLAMY, WAYNE, ROBERT C-5 VIRA-SAGAMINO-WEST, KAWASE, KOZO, TOMITA, MAMORU 1-47-6, HIGASHI-ASAHINA, SHIMAMURA, SEIICHI 1558, SHINOHARAO, KONIG, WOLFGANG RUHR-UNIVERSITY BOCHUM
• Format: Patent
• Language: English; French; German
• Published: 21.12.1994
• Edition: 5
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

Agent immunostimulant renfermant un peptide dérivé d'une lactoferrine ayant un effet modérateur de la libération des médiateurs inflammatoires des cellules du système immunitaire. Le peptide favorise la libération de leucotriène B4 de neutrophile polymorphonucléaire, induite par des activateurs tels que le calcium ionophore A23187. Il favorise également la libération d'histamine de mastocyte, induite par des activateurs tels que les cellules de Staphylococcus aureus productrices de alpha-toxine ou le calcium ionophore A23187. Le peptide est efficace à de faibles concentrations comprises entre 1 et 100 ppm. En favorisant la libération de tels médiateurs inflammatoires, le peptide peut potentialiser la réponse immunitaire des cellules et stimuler les défenses de l'hôte contre une maladie infectieuse. Ce nouvel agent immunostimulant est utile comme composant actif de substances pharmaceutiques, de produits hygiéniques, d'aliments cliniques, etc. pour la prévention et le traitement des infections bactériennes, fongiques et virales chez l'homme ou l'animal. PCT No. PCT/JP92/00275 Sec. 371 Date Feb. 19, 1993 Sec. 102(e) Date Feb. 19, 1993 PCT Filed Mar. 7, 1992 PCT Pub. No. WO93/18061 PCT Pub. Date Sep. 16, 1993.There is disclosed an immunostimulatory agent comprising a peptide derived from lactoferrin having activity to modulate the release of inflammatory mediators from cells of the immune system. The peptide promotes the release of leukotriene B4 from polymorphonuclear neutrophils induced by activators such as the calcium ionophor A23187, It also promotes the release of histamine from mast cells induced by activators such as alpha -toxin-producing Staphylococcus aureus cells or the calcium ionophor A23187. The peptide is effective at low concentrations within the range of 1 to 100 ppm. By promoting the release of such inflammatory mediators the peptide can potentiate the cellular immune response and stimulate the host defense against infectious disease. This newly discovered immunostimulatory agent is useful as an active component of pharmaceuticals, hygiene products, clinical foods, etc., for prevention and treatment of bacterial, fungal, and viral infectious in humans and animals.