Method for the resolution of racemic mixtures

The present invention relates to a method for the resolution of racemic mixtures of threo-alkyl-2-hydroxy-3-(4-methoxyphenyl)-3-(2-X-phenylthio)-propionates of formula 1 wherein R1 is an alkyl group and X is NO2, NH2 or an NH-R2 group with R2 representing an acyl group or an alkoxy carbonyl group, e...

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Bibliographic Details
Main Authors KAIRISALO PEKKA, KANERVA LIISA, SUNDHOLM OSKARI, HYTOENEN MARTTI
Format Patent
LanguageEnglish
French
German
Published 08.03.1995
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to a method for the resolution of racemic mixtures of threo-alkyl-2-hydroxy-3-(4-methoxyphenyl)-3-(2-X-phenylthio)-propionates of formula 1 wherein R1 is an alkyl group and X is NO2, NH2 or an NH-R2 group with R2 representing an acyl group or an alkoxy carbonyl group, each optionally substituted with one or more halogen atoms, comprising subjecting said racemic mixtures to reaction with an acylation reagent in an essentially anhydrous organic medium in the presence of a lipase.
Bibliography:Application Number: EP19940104620