Novel cephalosporin compounds

The present invention relates to novel cephalosporin compounds, pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof which possess potent and broad antibacterial activities. The compounds of the present invention have a (4-amino-...

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Main Authors BANG, CHAN-SIK, WOO, YOUNG-MIN, YEO, JAE-HONG, KIM, YONG-ZU, LIM, JONGAN, YANG, DUK-HO, OH, HUN-SEUNG, KIM, SAM-SIK, YIM, HYEON-JOO
Format Patent
LanguageEnglish
French
German
Published 06.07.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel cephalosporin compounds, pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof which possess potent and broad antibacterial activities. The compounds of the present invention have a (4-amino-1-substituted-alkapyrimidinium-4-yl)thiomethyl group in 3-position of the cephem nucleus and is specifically represented by the following formula(I): wherein: R is a hydrogen atom or, a C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl or -C(R)(R)COOH group wherein R and R are independently a hydrogen atom or a C1-4 alkyl group, or form a C3-7 cycloalkyl group together with the carbon atom to which they are attached; R is an unsubstituted or substituted amino, C1-4 alkyl or C3-7 cycloalkyl group; and n is an integer ranging from 2 to 7.
Bibliography:Application Number: EP19930120829