2,3-diphenyl-5-pyrrolyl-furan derivatives, processes and intermediates for their preparation and their use as anti-inflammatory, and anti-allergic and platelet aggregation inhibiting agents

• Main Authors: ISHIDA, MITSUGU, ADACHI, JUN, KATO, YUICHI, TANIGUCHI, TOSHIETSU, KAWAGOSHI, TOSHIYUKI, MIYAMOTO, TETSUO, TAMURA, TOMOAKI, KADOZAKI, TETSUO
• Format: Patent
• Language: English; French; German
• Published: 18.05.1994
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Diphenylpyrrolylfuran derivatives represented by the following formula (I): wherein R1 and R2 may be the same or different and independently represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, or a lower alkylsulfenyl group; m and n independently represent an integer of from 1 to 3; R3 represents a hydrogen atom or a lower alkyl group, R4 represents a hydrogen atom, a lower alkyl group, or a lower acyl group; and R5 represents a hydrogen atom, a lower alkyl group which may have one or more suitable substituents, a lower alkoxy- or an aryloxy-carbonyl group, an acyl group, or a sulfonyl group, and pharmaceutically acceptable salts thereof are disclosed. The compounds disclosed are useful as anti-inflammatory agents, anti-allergic agents, anti-platelet agents; and synthetic intermediates for the preparation of the coumpounds of the formula (I> represented by the following formula (II):