RECOMBINANT VIRUS EXPRESSING CARCINOEMBRYONIC ANTIGEN AND METHODS OF USE THEREOF

• Main Authors: SCHLOM, JEFFREY, KANTOR, JUDITH
• Format: Patent
• Language: English; French; German
• Published: 02.03.1994
• Edition: 5
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

L'invention a trait à un antigène carcino-embryonnaire (CEA)/virus de la vaccine recombiné ou un autre vecteur viral exprimant un CEA sur la surface de cellules contaminées et provoquant une réaction immune in vivo développée contre un CEA ou des cellules exprimant un CEA, ainsi qu'à une composition pharmaceutique le contenant. L'invention concerne également des procédés de traitement de patients contenant des cellules de carcinome dans lesquelles un CEA est exprimé, ainsi que des procédés de stimulation du système immunitaire contre le CEA. The present invention relates to a recombinant carcinoembryonic antigen (CEA)/vaccinia virus or other viral vector which expresses CEA on the surface of infected cells and which elicits an immune response in vivo directed against CEA or cells expressing CEA and a pharmaceutical composition containing same. The invention also relates to methods of treating patients having tumors in which CEA is expressed and methods of stimulating the immune system against CEA,