Phosphinyloxy propanaminium inner salt derivatives

The invention concerns the compounds of formula (I) where the substituents have various meanings, in free acid form or in salt, physiologically hydrolysable ester or pro-drug form. They can be prepared by various procedures, e.g. coupling accompanied by oxidation or thiolation and hydrolysis or thio...

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Main Authors BEBERNITZ, GREGORY R, PRASHAD, MAHAVIR, SMITH, HOWARD C, ANDERSON, ROBERT CHARLES, WILLHAUER, EDWIN B, HUGHES, JEFFREY W, FRASER, JAMES D, KAPA, PRASAD K
Format Patent
LanguageEnglish
French
German
Published 13.08.1997
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention concerns the compounds of formula (I) where the substituents have various meanings, in free acid form or in salt, physiologically hydrolysable ester or pro-drug form. They can be prepared by various procedures, e.g. coupling accompanied by oxidation or thiolation and hydrolysis or thiolysis, or by reduction to amino of a nitro substituent on an aromatic ring. They possess hypoglycemic activity and are thus indicated for use in the treatment of diabetes.
Bibliography:Application Number: EP19930810406