Controlled-release pharmaceutical formulations

A pharmaceutical controlled release formulation is disclosed which does not substantially disintegrate but gradually releases a physiologically active substance in the gastrointestinal tract and which comprises a granulation product - (granules) obtained by adding release controlling agent (e.g. an...

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Bibliographic Details
Main Authors KAJIYAMA, ATUSHI, SOEISHI, YOSHIAKI, HIKOSAKA, TAMIO, TOMURO, KOUJI, HIGUCHI, SABURO, FUKUI, MUNEO, MASUYAMA, SHIGERU, ARUGA, MASAYOSHI
Format Patent
LanguageEnglish
French
German
Published 24.03.1993
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A pharmaceutical controlled release formulation is disclosed which does not substantially disintegrate but gradually releases a physiologically active substance in the gastrointestinal tract and which comprises a granulation product - (granules) obtained by adding release controlling agent (e.g. an aqueous suspension of a water insoluble macromolecular substance, an aqueous emulsion thereof, a water containing organic-solvent solution thereof, or water) to a mixture of i) physiologically active substance and ii) carrier substance (e.g. crystalline cellulose) in an amount of at least 50% by weight based on the weight of the product, and granulating the resultant mixture. The active substance containing granules have a high mechanical strength, disperse widely in the gastrointestinal tract when administered, are water permeable but do not substantially disintegrate in the gastrointestinal tract.
Bibliography:Application Number: EP19920203126