THIAZOLIDINE-2,4-DIONE DERIVATIVE, SALT THEREOF, AND PRODUCTION OF THE SAME

A novel thiazolidine-2,4-dione derivative with hypoglycemic and aldose reductase inhibitory activities, represented by the general formula (1) or (2), a salt thereof, a process for producing the same, and a medicine containing the same, wherein R and R may be the same or different from each other an...

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Main Authors OHNOTA, MICHIRO, MURAKAMI, KOJI, OKAMURA, KYUYA, OHASHI, MITSUO, HIRATA, YOSHIHIRO
Format Patent
LanguageEnglish
French
German
Published 23.09.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A novel thiazolidine-2,4-dione derivative with hypoglycemic and aldose reductase inhibitory activities, represented by the general formula (1) or (2), a salt thereof, a process for producing the same, and a medicine containing the same, wherein R and R may be the same or different from each other and each represents hydrogen or lower alkyl; R represents phenyl naphthyl, benzoyl, 5- or 6- membered heterocycle or a benzene-containing condensed ring thereof, all of which may have at least one substituent; A represents carbonyl, sulfonyl or a free bond; and B represents lower alkylene, lower alkenylene or a free bond, in formula (2) R represents hydrogen or lower alkyl, and R and R are as defined above.
Bibliography:Application Number: EP19920905305