Oxadiazolylmethylpurines, their preparation, and their pharmaceutical use

• Main Authors: DEBRECZENI, LORAND, KORBONITS, DEZSOE, MINKER, EMIL, MARMAROSI NEE KELLNER, KATALIN, VIRAG, SANDOR, TOTH NEE ITO, KATALIN, SZOMOR NEE WENDELE, MARIA, SZATMARI, ISTVAN, HEJA, GERGELY, KOERMOECZY, PETER, SZABO, MARIA
• Format: Patent
• Language: English; French; German
• Published: 03.06.1992
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Die Erfindung betrifft neue 3H-Purine der allgemeinen Formel I in der R H oder C1-4-Alkyl bedeutet, und ihre physiologisch verträglichen Salze sowie ihre Herstellung und Arzneimittel, welche die Verbindungen der allgemeinen Formel I und ihre Salze enthalten. Die Verbindungen der Formel I stellen hochwirksame Broncholytika und Antiasthmatika dar, deren besonderer Vorteil darin besteht, daß sie keine unerwünschten Nebenwirkungen auf das Zentralnervernsystem und keine unerwünschten Herzwirkungen aufweisen. The invention relates to novel 3H-purines of the general formula I in which R denotes H or C1-4-alkyl, and their physiologically tolerable salts, as well as their preparation and medicaments which contain the compounds of the general formula I and their salts. The compounds of the formula I are highly active broncholytics and antiasthmatics, whose particular advantage is that they do not have any undesired side effects on the central nervous system or any undesired cardiac effects.